S-nitroso-N-acetylcysteine attenuates liver fibrosis in experimental nonalcoholic steatohepatitis [Corrigendum]
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License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Ltd. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php Drug Design, Development and Therapy 2013:7 971–972 Drug Design, Development and Therapy Dovepress
منابع مشابه
S-nitroso-N-acetylcysteine attenuates liver fibrosis in experimental nonalcoholic steatohepatitis
S-Nitroso-N-acetylcysteine (SNAC) is a water soluble primary S-nitrosothiol capable of transferring and releasing nitric oxide and inducing several biochemical activities, including modulation of hepatic stellate cell activation. In this study, we evaluated the antifibrotic activity of SNAC in an animal model of nonalcoholic steatohepatitis (NASH) induced in Sprague-Dawley rats fed with a choli...
متن کاملN-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis
J Nutr. 2008 Oct;138(10):1872-9. N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis. Baumgardner JN, Shankar K, Hennings L, Albano E, Badger TM, Ronis MJ. Departments of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. BACKGROUN D: A "2-hit" model for nonalcoholic steatohepatitis (NASH) h...
متن کاملN-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis.
A "2-hit" model for nonalcoholic steatohepatitis (NASH) has been proposed in which steatosis constitutes the "first hit" and sensitizes the liver to potential "second hits" resulting in NASH. Oxidative stress is considered a candidate for the second hit. N-acetylcysteine (NAC), an antioxidant, has been suggested as a dietary therapy for NASH. We examined the effects of NAC in a rat total entera...
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Background: Nonalcoholic fatty liver disease (NAFLD) includes steatosis, nonalcoholic steatohepatitis, fibrosis and liver cirrhosis. The oxidative stress enzymes are the diagnostic markers to prediction of histologic status of liver in nonalcoholic steatohepatitis disease. The aim of the study was to assessment of relationship between serum Zinc (Zn) levels with pathologic manifestation in pati...
متن کاملPrevention of Nonalcoholic Steatohepatitis in Rats by Two Manganese-Salen Complexes
Background: Nonalcoholic steatohepatitis (NASH), a progressive stage of nonalcoholic fatty liver disease (NAFLD), is characterized by steatosis with inflammation. Investigations have suggested that oxidative stress may play an important role in the progress of NAFLD to NASH. To provide further insights into beneficial effects of antioxidants in NASH prevention, we employed two manganese-supero...
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عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2013